Matrix tablets

ABSTRACTTreatment of hypertension with conventional dosage forms is not effective as the drugs do not reach the site of action in appropriate concentration and it is also requiring dosing. Thus, an effective and safe therapy of hypertension disorder using specific drug delivery system is a challenging task to the pharmaceutical technologists. Most commonly used method of modulating the drug release is to include it in a matrix system, because of their flexibility, hydrophilic polymer matrix system is widely used in oral controlled drug delivery to obtain a desirable drug release profile, cost effectiveness and broad regulatory acceptance. In present study we have prepared matrix tablet formulations using Prazosin as model drug and Ethyl Cellulose, Two grades of Hydroxy propyl methyl cellulose- HPMC-K4M &HPMC-K100M as polymers in different ratios. The developed matrix tablets were evaluated for different physical chemical evaluations like drug content, hardness, friability, swelling index etc. All the formulations had shown the results within prescribed limits. The In vitro drug release study indicates that formulation F7 containing EC, HPMC K100M in 1:2 ratio shown good release pattern for 14 hours compare to other formulations. The short-term stability study proven no change in the formulation upon ageing and it indicates good stability. Keywords: Prazosin, Matrix tablets, Ethyl Cellulose and HPMC-K4M & K100M.

Various conventional dosage forms are available in the market of the plants boswellia and liquorice. The drawbacks associated with their conventional dosage forms which are fluctuation in drug blood level, patient’s inconvenience, poor patient compliance, increased chances of missing the dose of a drug high dose potency etc. can be solved by formulating sustained release formulations of  these herbal drugs. Different formulations of boswellia and liquorice sustained release tablets were formulated using wet granulation method. The tablets were subjected to physicochemical studies, in vitro drug release studies, kinetic modeling and stability studies to find out the best formulation. Drug content was carried out by HPLC fitted with a C18 column using UV detector. The in vitro release studies were conducted for 24h using USP type 2 apparatus. The dissolution profile comparison of the prepared batches was done. The dissolution data profile was fitted into zero order, first order, Higuchi and Korsemeyer-Peppas models to identify the pharmacokinetics and mechanism of drug release. In vivo anti-inflammatory effects of the optimized formulations were evaluated by carrageenan-induced hind paw edema method. The results of the accelerated stability study for six months revealed that storage conditions were not found to have made any significant changes. The release of formulation F-4 of boswellic acid and F-6 of liquorice was prolonged for 24h and once daily matrix tablet was formulated.