Anti-inflammatory

ABSTRACTCosmetics are the external preparations, which are applied to the skin, hair, nails for various purposes like protecting, covering, colouring, beautifying, cleansing and nourishing. Lip Balm is one of the beauty products that soothe dryness and chapping and assist sore lips to experience better. Antioxidants can be used to protect the skin from damage caused by oxidation to prevent premature aging. Walnut Oil is an effective antioxidant and anti-inflammatory properties which are help to protect from several harmful effects to the lips. Red Dragon Fruit (Hylocereus polyrhizus) contains an effective amaranth colorant referred to as betacyanin pigment. The application of natural colour derived from the Red Dragon fruit is safe and can act as a natural dye that has anti-inflammatory and antiulcer properties which do not affect the colour and texture of the lip balm. The dragon fruit herbal lip balm is a natural, effective, and sustainable alternative to traditional lip balms. Its unique blend of ingredients provides excellent moisturization, protection, and antioxidant benefits, making it an attractive option for consumers seeking a healthy and natural lip care solution. The aim of the research was to formulate and evaluate herbal lip balm incorporated with walnut oil and red dragon fruit. Keywords: Walnut Oil, Antioxidant, Anti-inflammatory, Red Dragon Fruit, Herbal Lip balm.

ABSTRACTThe objective of the present study was to assess the anti-inflammatory potential of combined extracts of Murraya koenigii and Mangifera indicausing the carrageenan induced rat paw edema method. The extraction yield in methanol was found to be 26.8 % for Murraya koenigii and 31.6 % for Mangifera indica. The findings of preliminary phytochemical analysis suggest the presence of alkaloids, saponin glycosides, phenolics, terpenoids, and flavonoids in the leaf of the Murraya koenigii while alkaloids and glycosides were not found to be present in Mangifera indica. The total phenolic content of the hydroalcoholic extracts of M. koenigii and M.indica were 34.27±1.7 and 43.11±2.1 GAE mg/g, respectively. The phenolic content was highest in the combined extract (MSE:MIE, 1:2) of all the three combinations with total phenolics 61.22±4.1GAE mg/g. The extracts were individually and in combination (1:1, 1:2 & 2:1) subjected to determination of anti-inflammatory potential by carrageenan induced rat paw edema method using ibuprofen as the standard drug. Ibuprofen at dose of 10 mg/Kg inhibited 69.23% edema after 4h of administration whereas the maximum edema inhibition exhibited by the combined extracts was 55.22% (MKE:MIE, 1:2)  at the end of 4h. Keywords: Murraya koenigii, Mangifera indica, carrageenan, Anti-inflammatory,paw edema, Extract

Various conventional dosage forms are available in the market of the plants boswellia and liquorice. The drawbacks associated with their conventional dosage forms which are fluctuation in drug blood level, patient’s inconvenience, poor patient compliance, increased chances of missing the dose of a drug high dose potency etc. can be solved by formulating sustained release formulations of  these herbal drugs. Different formulations of boswellia and liquorice sustained release tablets were formulated using wet granulation method. The tablets were subjected to physicochemical studies, in vitro drug release studies, kinetic modeling and stability studies to find out the best formulation. Drug content was carried out by HPLC fitted with a C18 column using UV detector. The in vitro release studies were conducted for 24h using USP type 2 apparatus. The dissolution profile comparison of the prepared batches was done. The dissolution data profile was fitted into zero order, first order, Higuchi and Korsemeyer-Peppas models to identify the pharmacokinetics and mechanism of drug release. In vivo anti-inflammatory effects of the optimized formulations were evaluated by carrageenan-induced hind paw edema method. The results of the accelerated stability study for six months revealed that storage conditions were not found to have made any significant changes. The release of formulation F-4 of boswellic acid and F-6 of liquorice was prolonged for 24h and once daily matrix tablet was formulated.