carrageenan

ABSTRACTThe objective of the present study was to assess the anti-inflammatory potential of combined extracts of Murraya koenigii and Mangifera indicausing the carrageenan induced rat paw edema method. The extraction yield in methanol was found to be 26.8 % for Murraya koenigii and 31.6 % for Mangifera indica. The findings of preliminary phytochemical analysis suggest the presence of alkaloids, saponin glycosides, phenolics, terpenoids, and flavonoids in the leaf of the Murraya koenigii while alkaloids and glycosides were not found to be present in Mangifera indica. The total phenolic content of the hydroalcoholic extracts of M. koenigii and M.indica were 34.27±1.7 and 43.11±2.1 GAE mg/g, respectively. The phenolic content was highest in the combined extract (MSE:MIE, 1:2) of all the three combinations with total phenolics 61.22±4.1GAE mg/g. The extracts were individually and in combination (1:1, 1:2 & 2:1) subjected to determination of anti-inflammatory potential by carrageenan induced rat paw edema method using ibuprofen as the standard drug. Ibuprofen at dose of 10 mg/Kg inhibited 69.23% edema after 4h of administration whereas the maximum edema inhibition exhibited by the combined extracts was 55.22% (MKE:MIE, 1:2)  at the end of 4h. Keywords: Murraya koenigii, Mangifera indica, carrageenan, Anti-inflammatory,paw edema, Extract

ABSTRACTThe objective of the present work is to evaluate and establish the potential anti-inflammatory and antioxidant action of the Resveratrol and BioPerineÒ combination against DPPH was found to be 57.01µg/mL. The Resveratrol and BioPerineÒ combination was able to reduce the inhibition after the third hour significantly (p<0.01) exhibiting 50.87% reduction in edema volume. Keywords: Resveratrol, BioPerine, antioxidant, anti-inflammatory, DPPH, Rat paw edema, carrageenan

The inflammation is a complex process, which is frequently associated with pain and involves several events. Anti-inflammatory compounds can act on many steps of pathophysiological process by blocking the biosynthesis of proinflammatory mediators; by direct interaction with a key enzyme or by decreasing enzyme expression. The pomegranate, (Punica granatum L.)  has been used extensively in the folk medicine for a number of therapeutic purposes. In the present investigation antiinflammatory activity of pomegranate whole fruit (EPWF) and seeds (EPS) ethanol extracts and synthetic ellagic acid(EA) was evaluated in swiss albino mice using ethylphenylpropiolate and carrageenan induced edema models. EA and EPWF exhibited inhibitory effect (P