Punica granatum

Biofilms are the main cause for increase in virulence and antibiotic resistance of microorganisms. Both gram positive and gram negative pathogens are known to produce biofilms. Due to the production of biofilm the bacteria adhere to the surface strongly and are protected from any antibiotic agents. The present study is aimed to inhibit the biofilms produced by gram negative E. coli isolated from UTI samples (UPEC), using plant extracts. Plants like Magnifera indica, Punica granatum, Catharanthus roseus and Manikara zapota were extracted to check for their antimicrobial as well as antibiofilm activity by well diffusion assay and biofilm assay. All the plant extracts were screened for antibiofilm activity. The result indicated that Punica granatum extract had a good inhibition capacity. The further scope in this field of study is to target AHL formation and hence, inhibit biofilm. The inhibition of biofilm helps in reducing many infections due to reduction in the virulence of bacteria that is mainly due to formation of biofilm, making the pathogens weak and more susceptible to antimicrobial agents.

The inflammation is a complex process, which is frequently associated with pain and involves several events. Anti-inflammatory compounds can act on many steps of pathophysiological process by blocking the biosynthesis of proinflammatory mediators; by direct interaction with a key enzyme or by decreasing enzyme expression. The pomegranate, (Punica granatum L.)  has been used extensively in the folk medicine for a number of therapeutic purposes. In the present investigation antiinflammatory activity of pomegranate whole fruit (EPWF) and seeds (EPS) ethanol extracts and synthetic ellagic acid(EA) was evaluated in swiss albino mice using ethylphenylpropiolate and carrageenan induced edema models. EA and EPWF exhibited inhibitory effect (P