Antidiabetic Effect of Polyherbal Formulation Instreptozotocin Induced Diabetic Rats

The objective of the present study is planned to investigate the antidiabetic potential of polyherbal preparation in streptozotocin induced diabetic rats. Diabetes was induced in rats by single intraperitoneal injection of streptozotocin (50 mg/kg b.wt.). After 72 hrs rats with marked hyperglycaemia (fasting blood glucose ≥250 mg/dl) were selected and used for the study. Antidiabetic effect was evaluated by oral administration of polyherbal formulation consisting of (Helicteres isora, Portulaca oleracea, and Caralluma attenuata) at doses of 100, 200 and 400 mg/kg b.wt. for 28 days. In streptozotocin diabetic rats, oral administration of polyherbal formulation in dose dependent manner show reduced blood glucose level, which was comparable to that of reference standard glibenclamide (5 mg/kg b.wt.). Significant decrease in body weight also was observed with diabetic control, which was partially restored upon administration of polyherbal formulation. Hence, these findings demonstrate that polyherbal formulation has potential to treat diabetes mellitus and its complications.