streptozotocin

Objective: The aim of this study was to evaluate the pharmacological effects of an aqueous extract of leaves, flowers and pods of Crotalaria retusa (Fabaceae) on the blood glucose levels of streptozotocin-induced diabetic rats. Results: The phytochemical test revealed the presence of polyphenols, flavonoids, catechin and gallic tannins, quinonic compounds, alkaloids, sterols and polyterpenes. However, saponins were not detected in the aqueous extract of Crotalaria retusa. Administration of the aqueous extract of Crotalaria retusa at doses of 1000 and 600 mg/kg body weight resulted in a significant decrease in blood glucose levels in diabetic rats from day 28 until the end of treatment (84 days). The aqueous extract of Crotalaria retusa appears to have antidiabetic properties. These results would justify the use of this plant in traditional medicine for the treatment of diabetes.

The objective of the present study is planned to investigate the antidiabetic potential of polyherbal preparation in streptozotocin induced diabetic rats. Diabetes was induced in rats by single intraperitoneal injection of streptozotocin (50 mg/kg b.wt.). After 72 hrs rats with marked hyperglycaemia (fasting blood glucose ≥250 mg/dl) were selected and used for the study. Antidiabetic effect was evaluated by oral administration of polyherbal formulation consisting of (Helicteres isora, Portulaca oleracea, and Caralluma attenuata) at doses of 100, 200 and 400 mg/kg b.wt. for 28 days. In streptozotocin diabetic rats, oral administration of polyherbal formulation in dose dependent manner show reduced blood glucose level, which was comparable to that of reference standard glibenclamide (5 mg/kg b.wt.). Significant decrease in body weight also was observed with diabetic control, which was partially restored upon administration of polyherbal formulation. Hence, these findings demonstrate that polyherbal formulation has potential to treat diabetes mellitus and its complications.