Comparative Study on Effect of Natural and Synthetic Super disintegrants in the Formulation of Fast Dissolving Palatable Tablets of an Antiemetic Drug

The main objective of the present work was to formulate fast-dissolving tablets of an antiemetic drug using natural (xanthum gum, Isapgula husk and banana powder) and synthetic (crospovidone and croscarmelose) superdisintegrants by direct compression method and compare their effect on tablet formulations. This study was also aimed to find out the best superdisintegrants for the prepared formulations with better disintegrating property and better in-vitro dissolution profile. The infra red spectra of pure drug with different excipients showed no shift in peak, hence no interaction between drugs and excipients. The tablets were subjected to the various parameters like weight variation, hardness, thickness, friability, dispersion time, disintegration time, drug content and in-vitro drug release. All the powder blend showed good to acceptable flow ability as the powder blends showed angle of repose below 30°, bulk density in the range between 0.486 to 0.522 g/cm3, tapped density in the range between 0.568-0.590 g/cm3, and the compressibility index was found to be between 12.71 and 14.98 which ensures the powder blends may be suitable for direct compression. In vitro disintegration time for all formulation batches i.e. F1 to F15 showed wide variation in the range between 23 to 36 seconds. Percentage drug content for all tablets were in between 94.4 to 97.25%. In vitro dissolution study for all tablets was performed and formulation F11 containing Isapgula husk as natural superdisintegrants showed 97.25% drug release within 8 minutes, which might be due to swelling ability of Isapgula husk.