Domperidone maleate

The main objective of the present work was to formulate fast-dissolving tablets of an antiemetic drug using natural (xanthum gum, Isapgula husk and banana powder) and synthetic (crospovidone and croscarmelose) superdisintegrants by direct compression method and compare their effect on tablet formulations. This study was also aimed to find out the best superdisintegrants for the prepared formulations with better disintegrating property and better in-vitro dissolution profile. The infra red spectra of pure drug with different excipients showed no shift in peak, hence no interaction between drugs and excipients. The tablets were subjected to the various parameters like weight variation, hardness, thickness, friability, dispersion time, disintegration time, drug content and in-vitro drug release. All the powder blend showed good to acceptable flow ability as the powder blends showed angle of repose below 30°, bulk density in the range between 0.486 to 0.522 g/cm3, tapped density in the range between 0.568-0.590 g/cm3, and the compressibility index was found to be between 12.71 and 14.98 which ensures the powder blends may be suitable for direct compression. In vitro disintegration time for all formulation batches i.e. F1 to F15 showed wide variation in the range between 23 to 36 seconds. Percentage drug content for all tablets were in between 94.4 to 97.25%. In vitro dissolution study for all tablets was performed and formulation F11 containing Isapgula husk as natural superdisintegrants showed 97.25% drug release within 8 minutes, which might be due to swelling ability of Isapgula husk.

Domperidone maleate is dopamine receptor blocking agent and first choice drug in antiemetic category. Major drawback of this drug is its very low water solubility and low erratic absorption from gastrointestinal tract. The purpose of present investigation was to increase the solubility and dissolution rate of Domperidone maleate by preparation of liquisolid compacts and preparation of fast dissolving tablets by direct compression method. Superdisinegrants used were Crospovidone, Croscarmellose Sodium and Sodium Starch glycolate. Propylene glycol, Polyethylene glycol 200, Polyethylene glycol 400 was used as a liquid vehicle and Avicel-PH 102, Aerosil-200 as a carrier and coating material respectively. Tablets were prepared and evaluated for various parameters like hardness, thickness, friability, weight variation, wetting time, in-vitro disintegration time, in-vitro dispersion time, in-vitro dissolution study. Formulation F13 showed 95.5 % drug release within 30 min. It was inferred that liquisolid compact technique is useful in enhancement of dissolution rate and bioavailability of Domperidone maleate.