Biosynthesis, antimicrobial effect and DNA damage study of gold nanoparticles with Cinnamomum zeylanicum

Objective of the study was to synthesize gold nanoparticles using bark of Cinnamomum zeylanicum and study its antimicrobial property and DNA damage. Gold nanoparticles were synthesized using powdered aqueous extract of bark of Cinnamomum zeylanicum. Green synthesis method was used. It was done using two different concentrations of Chloroauric acid 2mM and 1mM. Characterization studies were done with the synthesized nanoparticles. They were also checked for its antibacterial and antifungal activity through microbiological techniques. Also the plant extract and solution containing were tested for DNA damage through Agarose gel electrophoresis. Cinnamomum zeylanicum supported the synthesis of gold nanoparticles. Characterization studies like FTIR, UV – VIS spectroscopy, SEM, and XRD were carried out. GNPs in the range of 35 – 80nm were obtained. The antibacterial and antifungal study showed clear zones of inhibition of microbial growth. The image projected through UV – Transilluminator proves that there is no DNA damage. The results indicate that Cinnamomum zeylanicum is a good support plant for synthesis of gold nanoparticles and also the biologically synthesized GNPs has antimicrobial activity and also it is safe since it does not damage DNA.