Aditi Dubey

The present study has been made to study the effects of microcystin on the physiology of cockroach. Toxic effects of microcystin have been reported in rat, fish etc. this toxin effects the liver thus the metabolism of the organism is much affected. In cockroach, intracoelomic treatment of Microcystis extract showed some fluctuations in concentration of protein fractions especially in fractions 3, 4, 5 and 6. A common decrease in protein concentration is observed in 4, 5 and 6 but fraction 3 showed an increase in concentration. Fractions 7 and 8 failed to separate both in male and female cockroach. Reduced protein concentration for fraction 4 and 6 observed in male cockroach. The concentration of protein in the haemolymph generally decreases due to the microcystin treatment. Similar observation was recorded for the insects in spectrophotometric analysis of protein concentration.

The aim of the present study is to evaluate the effect of ethanolic extract of Leptadaenia reticulata for immunomodulating activity. The ethanolic extract of plant of Leptadaenia reticulata holds potential as a protective agent against cytotoxic drugs. The extracts when studied on humoral and cell mediated immunity in normal, as well as cyclophosphamide induced immunosuppressed rats. It produced both increase for some parameters and decrease response in some other parameters. The present investigation established pharmacological evidence to support the folklore claim that it is an immunomodulating drug plant.

The aim of the present study is to evaluate the effect of aqueous extract of Leptadaenia reticulata for immunomodulating activity. The aqueous extract of plant of Leptadaenia reticulata holds potential as a protective agent against cytotoxic drugs. The extracts when studied on humoral and cell mediated immunity in normal, as well as cyclophosphamide induced immunosuppressed rats, it produced an increase in carbon clearance, humoral antibody (HA) titre, delayed type hypersensitivity (DTH) and white blood cell (WBC) count in a dose dependent manner. The aqueous extract also enhanced interleukin-2 (IL-2) level in a dose dependent manner while the IL-6 showed almost stable level. The present investigation established pharmacological evidence to support the folklore claim that it is an immunomodulating.