Asish Bhaumik

The objective of the present work was the synthesis of 1-[5-acetyl-4 (4-substituted phenyl)-2,6-dimethyl-1,4-dihydroxypyridine-3-yl]-ethan-1-one and evaluation of in vitro anticancer activity. Based on this a new series of compound had been planned to synthesize by reacting acetyl acetone with various aromatic aldehydes in the presence of ammonium acetate. The in vitro anticancer activities were carried out against Human small cell lung DMS 114 cell line and Human colon cancer cell line HCC 2998 and MTT assay was used to analyze the cell growth inhibition of the both. The results had been displayed that compound B1-B4 were possessed an excellent anticancer activity (at 25 µg/ml) against both Human small cell lung DMS 114 cancer cell line and Human colon cancer cell line HCC 2998 and doxorubicin (at 10µg/ml) was used as a standard drug for Human small cell lung DMS 114 cancer cell line and 5-Fluro uracil (5-FU) for Human colon cancer cell line HCC 2998. In the present study IC50  values below 4 µg/ml were displayed by the  compound B1 (IC50 of 4.0 µg/ml), B2 (IC50 of 3.4 µg/ml), B3 (IC50 of 3.2 µg/ml) and  B4 (IC50 of 3.1 µg/ml) against Human  small cell lung DMS 114 cancer cell line and  B1( IC50 of 3.5 µg/ml), B2 (IC50 of 3.2 µg/ml), B3 (IC50 of 2.9 µg/ml) and B4 (IC50 of 2.9 µg/ml) against Human colon cancer cell line HCC 2998. The IC50 values of standard drugs doxorubicin and 5-FU were found to be 1. 2 µg/ml and 1.1 µg/ml.

Jarul (it is also known as Banaba) is a flowering plant that grows in warm climate like the Philippines, India and others.In India, Jarul  is also used in Ayurvedic medicine for the treatment of diabetes. The Jarul leaves and flowers contain corrosolic acid, a substance being studied for its insulin like effect of lowering the glucose in the body. Jarul is also being studied as a weight-loss supplement for its ability to delay or reduce the absorption of carbohydraes. Jarul is also rich in vitamins and minerals including zinc and magnesium. Jarul is also rich in dietary fibers. The scientific name the Jarul or Banaba is Lagerstroemia speciosa L (Lythraceae). The main objective of the present work is to evaluate the Antiinflammatory activity of fruits seeds of Lagerstroemia speciosa L. Based on this, a new series of constituents had been planned to extract by Ethanol (ELN),Methanol (MLN), Acetone (ACT)and Chloroform (CLF)from the fruit seeds of  Lagerstroemia speciosa L. The in-vivo Anti-inflammatory activity was carried out by carrageenan induced paw edema method in rats. The present experimental data displayed that all the extracts exhibited mild to good anti-inflammatory activity. All the extracts exhibited highest Anti-inflammatory activity at 120 min with the percentage protection of 63.18% (ELN), 48.95% (MLN), 44.95%(ACT) and 65.5%(CLF). Among these four extracts ELN and CLF displayed the highest antiinflammatory activity.