Carrageenan

Jarul (it is also known as Banaba) is a flowering plant that grows in warm climate like the Philippines, India and others.In India, Jarul  is also used in Ayurvedic medicine for the treatment of diabetes. The Jarul leaves and flowers contain corrosolic acid, a substance being studied for its insulin like effect of lowering the glucose in the body. Jarul is also being studied as a weight-loss supplement for its ability to delay or reduce the absorption of carbohydraes. Jarul is also rich in vitamins and minerals including zinc and magnesium. Jarul is also rich in dietary fibers. The scientific name the Jarul or Banaba is Lagerstroemia speciosa L (Lythraceae). The main objective of the present work is to evaluate the Antiinflammatory activity of fruits seeds of Lagerstroemia speciosa L. Based on this, a new series of constituents had been planned to extract by Ethanol (ELN),Methanol (MLN), Acetone (ACT)and Chloroform (CLF)from the fruit seeds of  Lagerstroemia speciosa L. The in-vivo Anti-inflammatory activity was carried out by carrageenan induced paw edema method in rats. The present experimental data displayed that all the extracts exhibited mild to good anti-inflammatory activity. All the extracts exhibited highest Anti-inflammatory activity at 120 min with the percentage protection of 63.18% (ELN), 48.95% (MLN), 44.95%(ACT) and 65.5%(CLF). Among these four extracts ELN and CLF displayed the highest antiinflammatory activity.

The root bark of Plumbago zeylanica Linn has potent analgesic and anti-inflammatory activity which has been used in many formulations of Indian system of medicine in treating Cancer. Since less information is available on the effects of hydro alcoholic extract of Plumbago zeylanica on inflammation and nociception, the present study was designed. To study the analgesic and anti-inflammatory activity of the hydro alcoholic extract of root bark of Plumbago zeylanica Linn. Soxhlet extraction of root bark powder done using 85% Methanol and Water 15% to obtain test drug. Analgesic effect was studied using hot plate and tail immersion analgesia in rat. Anti-inflammatory activity was investigated through in vitro Human Red Blood Cell Membrane protective activity and, Carrageenan induced rat paw edema and Complete Freund’s Adjuvant induced chronic inflammatory model in rat. Analgesic activity of the extract was studied by hot plate and tail immersion method revealed significant activity at 350 mg/kg b.wt dosage on comparing with weak analgesic standard drug Paracetamol. Studies of extract on both acute and chronic model of inflammation induced by Carrageenan and Complete Freund’s Adjuvant in rat showed moderate anti -inflammatory action at primary phase of inflammation at the dosage of 250 mg/kg b.wt comparable with standard Indomethacin.