Bhabani Shankar Nayak

The current paper was a shot to style a sustained unharness dosage kind victimisation varied grades of hydrophilic polymers, Hypromellose or Hydroxy- propyl alkyl radical polysaccharide (HPMC K15M, HPMC K100M) and Chitosan additionally incorporated as rate retarding material. Laboratory scale batches of Six tablet formulations were ready by wet granulation technique (Low shear). Micromeritic properties of the granules were evaluated before compression. Tablets were characterized as crushing strength, friability, weight variation, thickness, Drug content or assay and evaluated for in-vitro unharness pattern for fifteen unit of time victimisation Phosphate buffer of suitable pH at 37±0.5°C. Results and discussion: The results obtained discovered that HPMC K15M, Chitosan and Ethylcellulose at an acceptable concentration formulation (F6) was able to sustain the drug unharness for fifteen hours and followed Higuchi pattern similar Fickian diffusion. moreover production validation scale batches were designed supported laboratory scale best batch and charged for stability testing. it had been found that every one parameters were at intervals the limit of acceptance. There was no chemical interaction found between the drug and excipients throughout FT-IR and DSC study thought of in the present investigation. therefore it may be over that combinely polymers at an acceptable concentration will effectively be formulate to sustain the drug unharness.

The plant Gmelina arborea has been traditionally used in India for several medicinal purposes like anthelmintic, diuretic, antibacterial, antipyretic, antioxidant and antidiabetic. The aim of the present study is to explore the antipyretic activity of G. arborea fruit extracts using ethanol, ethyl acetate, n-butanol and petroleum ether as solvents. The antipyretic activity was evaluated by inducing fever in experimental animals by injection of Brewer’s yeast at single dose of 300 mg/Kg, b.w. All data are verified for statistically significant by using one way ANOVA at 1 % level of significance (p < 0.01). All extracts showed antipyretic activity at 300 mg/Kg b.w., and the activity is well comparable with the standard drug, Aspirin. Petroleum ether is more effective as compared to other solvent extracts. It could be concluded that G. arborea fruits possess antipyretic activity.