Chitosan

Post harvest spoilage of fruits and vegetables is a common major problem and ways to reduce this spoilage are constantly explored. Chitosan is a natural polymer which obtained from deacetylation of chitin. It is a versatile polymer and its coating has proved to increase the shelf life of the fruits and vegetables. Present review summarizes different fruits and vegetables whose shelf-life has been increased using chitosan coatings. The coating being biodegradable and non-toxic for consumption has wide applications in the near future.

The current paper was a shot to style a sustained unharness dosage kind victimisation varied grades of hydrophilic polymers, Hypromellose or Hydroxy- propyl alkyl radical polysaccharide (HPMC K15M, HPMC K100M) and Chitosan additionally incorporated as rate retarding material. Laboratory scale batches of Six tablet formulations were ready by wet granulation technique (Low shear). Micromeritic properties of the granules were evaluated before compression. Tablets were characterized as crushing strength, friability, weight variation, thickness, Drug content or assay and evaluated for in-vitro unharness pattern for fifteen unit of time victimisation Phosphate buffer of suitable pH at 37±0.5°C. Results and discussion: The results obtained discovered that HPMC K15M, Chitosan and Ethylcellulose at an acceptable concentration formulation (F6) was able to sustain the drug unharness for fifteen hours and followed Higuchi pattern similar Fickian diffusion. moreover production validation scale batches were designed supported laboratory scale best batch and charged for stability testing. it had been found that every one parameters were at intervals the limit of acceptance. There was no chemical interaction found between the drug and excipients throughout FT-IR and DSC study thought of in the present investigation. therefore it may be over that combinely polymers at an acceptable concentration will effectively be formulate to sustain the drug unharness.

The present work aimed to develop a novel chitosan–PVA-based hydrogel sheet which forms an immobilizing matrix for silver nanoparticles (AgNPs). Silver nanoparticles were prepared by chemical reduction method. Silver nitrate was taken as the metal precursor and tri-sodium citrate as a reducing agent. These AgNPs were incorporated in to chitosan-PVA hydrogels in different concentrations (1%, 2%, 4% and 6%) to form F1, F2, F3 and F4 formulations respectively. The prepared chitosan and silver nanoparticle composite hydrogel sheets were characterized using U.V, FTIR, water absorption studies, SEM and Anti-microbial studies. The data shows the average diameter of AgNPs is in the range of 60-70 nm and is roughly spherical in shape. The AgNPs incorporated hydrogel sheets were bactericidal against Escherichia Coli (gram positive) and staphylococcus aureus (gram negative) and it showed good antibacterial effect by disc diffusion method. These results suggested that AgNPs incorporated chitosan hydrogel sheet could be a promising candidate for wound dressing applications.