C D Dayanand

Preeclampsia is a syndrome occurring in pregnancy that affects multiple systemic functions and leads to increased maternal and foetal morbidity as well as mortality. Ischemia Modified Albumin is a well-known marker of cardiac Ischemia. We aimed to test the hypothesis that variation in maternal serum Ischemia Modified Albumin (IMA) in preeclampsia during pre and post labour within 48 hours. A Longitudinal observational study was conducted between June 20 to April 2013in subjects with normal pregnancy (n=30), women with preeclampsia (n=30) and non-pregnant women (n=30) to evaluate the levels of IMA. The women studied were in 20-35thweeks of gestation visited obstetrics clinic in R.L. Jalappa hospital& Research center, Kolar, in a southern state of India. We estimated the maternal serum IMA levels before and after the delivery within 48 hours by using Albumin Cobalt Binding procedure. The results obtained were analysed by using Microsoft Excel 2013 and Quick R.  p value < 0.05 is considered as statistically significant. The Median IMA level in the preeclampsia group before delivery 1.071ABSU [inter quartile range (IQR) 0.453-1.708ABSU] and the same within 48hrs after delivery 1.013ABSU [inter quartile range (IQR) 0.526-1.774 ABSU)] was significantly lower (p

Preeclampsia is a metabolic syndrome and a major cause of maternal, fetal and neonatal morbidity and mortality that amounts to 10% of the pregnancy complications. To determine Malondialdehyde, protein carbonyl and total antioxidant status in preeclampsia and normal pregnant women during pre and post labour within 48 hours. A prospective case control study (n= 60), preeclampsia (n=30) and normal pregnant women (n=30) during pre and post labour within 48 hours. 3 ml of blood samples were collected during pre and post labour of normal pregnant and preeclampsia. MDA, Protein Carbonyl Content and Total Antioxidant Status were measured using spectrophotometric method. Mean ± SD were determined by using student “t” test. The Mean ± SD values of MDA µmol/L (4.7 ±1.8), Protein Carbonyls (168.9±70.5) nmol/, Total Antioxidant Status mmol/L (537 ± 451) in normal pregnant during pre-delivery and  MDA µmol/L(2.4 ±0.1), Protein Carbonyls (169±67.2)nmol/L , Total Antioxidant Status mmol/L (634.3 ± 241.2)  post-delivery presented. Similarly Mean ± SD values of MDA µmol/L (10.1 ±6.4), Protein Carbonyls (159±123.2)nmol/L , Total Antioxidant Status mmol/L (506.7 ± 287.6) in preeclampsia pre delivery and (6.1±6.1), (98.8±36.8), (680±362.3) post-delivery respectively. A well-known aspect in preeclampsia with increased concentrations of oxidative stress and decreased TAS. However the trend of increased TAS and declined oxidative stress during post labour of normal pregnant and preeclampsia which plays a significant role in pathophysiology of preeclampsia.