Preeclampsia

Preeclampsia (PE) is a leading cause of perinatal morbidity and mortality. Our aim of the study was to evaluate the association of oxidative stress and antioxidant defence systems with preeclampsia during pregnancy and after delivery. The study comprises a total of 52 subjects including PE women (n=27) and uncomplicated pregnant women (n=25) matched by age. Serummalondialdehyde (MDA), phospholipid hydroperoxide (PHP), superoxide dismutase (SOD), vitamin C and total antioxidant status (TAS) were estimated by spectrophotometric methods. Serum levels of MDA and PHP were significantly higher (p

Preeclampsia is a metabolic syndrome and a major cause of maternal, fetal and neonatal morbidity and mortality that amounts to 10% of the pregnancy complications. To determine Malondialdehyde, protein carbonyl and total antioxidant status in preeclampsia and normal pregnant women during pre and post labour within 48 hours. A prospective case control study (n= 60), preeclampsia (n=30) and normal pregnant women (n=30) during pre and post labour within 48 hours. 3 ml of blood samples were collected during pre and post labour of normal pregnant and preeclampsia. MDA, Protein Carbonyl Content and Total Antioxidant Status were measured using spectrophotometric method. Mean ± SD were determined by using student “t” test. The Mean ± SD values of MDA µmol/L (4.7 ±1.8), Protein Carbonyls (168.9±70.5) nmol/, Total Antioxidant Status mmol/L (537 ± 451) in normal pregnant during pre-delivery and  MDA µmol/L(2.4 ±0.1), Protein Carbonyls (169±67.2)nmol/L , Total Antioxidant Status mmol/L (634.3 ± 241.2)  post-delivery presented. Similarly Mean ± SD values of MDA µmol/L (10.1 ±6.4), Protein Carbonyls (159±123.2)nmol/L , Total Antioxidant Status mmol/L (506.7 ± 287.6) in preeclampsia pre delivery and (6.1±6.1), (98.8±36.8), (680±362.3) post-delivery respectively. A well-known aspect in preeclampsia with increased concentrations of oxidative stress and decreased TAS. However the trend of increased TAS and declined oxidative stress during post labour of normal pregnant and preeclampsia which plays a significant role in pathophysiology of preeclampsia.