C. Girish

Ulcers are the sores occurring on the lining of the digestive tract. The anti-ulcer activity of aqueous extract of seeds of Trigonella foenum graceum in combination with honey in rat ulcer models was performed. This was investigated in experimental rats by ethanol induced ulcer models and stress induced models. In both models the common parameter determined was ulcer index. Aqueous extract of Trigonella foenum graceum in combination with honey at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions in ethanol induced gastric ulcer and stress induced ulcer. The extract (250 mg/kg & 500 mg/kg) showed significant reduction in gastric volume and ulcer index as compared to control. This present study indicates that aqueous extract of Trigonella foenum graceum have potential antiulcer activity in the both the models. These results may further suggest that the extract was found to possess anti-ulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

Our aim in the present study was to evaluate the anti-obesity activity of Centella asiatica in high fat diet (HFD), Triton-X and Progesterone induced obesity in rats and mice. Ethanolic extract of Centella asiatica (EECA) was prepared and the extract is tested with different doses (100, 200 and 400mg/kg) and the efficiency of EECA is comparable to that of standard anti-obesity drug Orlistat (20mg/kg). Although food consumption was moderately increased in high fat diet fed rats, EECA administration significantly reduces weight gain in them. Serum total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) levels were significantly (P< 0.05) lowered, while high density lipoproteins (HDL) increased in EECA administered rats. Based on our results, we find that the EECA has potential anti-obesity activity.