Stress induced ulcer model.

Ulcers are the sores occurring on the lining of the digestive tract. The anti-ulcer activity of aqueous extract of seeds of Trigonella foenum graceum in combination with honey in rat ulcer models was performed. This was investigated in experimental rats by ethanol induced ulcer models and stress induced models. In both models the common parameter determined was ulcer index. Aqueous extract of Trigonella foenum graceum in combination with honey at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions in ethanol induced gastric ulcer and stress induced ulcer. The extract (250 mg/kg & 500 mg/kg) showed significant reduction in gastric volume and ulcer index as compared to control. This present study indicates that aqueous extract of Trigonella foenum graceum have potential antiulcer activity in the both the models. These results may further suggest that the extract was found to possess anti-ulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.