G.V. Naga Raju

To evaluate the anti-inflammatory and anti-diabetic potential of extracts Clitoria ternate flower (CTF) AND Tribulus terristris seed (TTS) by in-vivo pharmacological models using rats. Ternate flower (CTF) AND Tribulus terristris seed (TTS). Extraction by cold maceration techniques using hydro-alcoholic solvent. Evaluation of chemical constituents by various chemical tests. Acute toxicity studies as per OECD guidelines and calculation of ED 50 Anti-inflammatory activity by Carragenan induced rat paw models. Anti-diabetic activity by Alloxon induced diabetes in rats. Statistical analysis by Students t Test. Extraction by Cold Maceration method. Estimation of Phytochemicals by various chemical tests.(3) Acute Toxicity studies by OECD guidelines and dose selected were 200mg and 400mg/kg(4) Phytoconstituents are mostly presents in the Clitoria terneta flower and photosterols and flavonoids are not present in the Tribulus tertaris seed which are highly present in Clitoria terneta flower.Anti-inflammatory Activity of Clitoria ternata flower and Tribulus terristris seed highly seen in group III and V of CTF AND TFS. Least amount present in group II of 39% in CTF and 45% of group IV in TTS..Anti-diabetic Activity of Clitoria ternata flower and Tribulus terristris seed values are Mean ± SEM of Six Animals. Statistical Significance: a = p < 0.001 and b = p < 0.05 as compared to control From the acute toxicity studies the ED 50 of the extract were fixes as 200 and 400 mg/kg. The anti-inflammatory and anti-diabetic activity of both CTF & TTS were calculated by in-vivo methods using rat models. The 400mg/kg of both Clitoria ternata flower (CTF) and Tribulus terristris seed (TTS) extracts showed potential anti-inflammatory and anti-diabetic activity. Further studies are required for structural elucidation of the active component(s) involved in the anti-hyperglycaemic and anti-inflammatory activity of Tribulus terrestris L. and Clitoria ternate