MIEZAN Bilé Aka Patrice

ABSTRACT Gomphrena celosioides is a plant used in many traditional medicine recipes in West Africa, Southeast Asia, and South America. The present study aimed to evaluate the cellular immune response induced by the ethanolic extract of Gomphrena celosioides. The acute toxicity study of the extract used, conducted in rats according to OECD guideline no. 423, showed that the extract is non-toxic. The effect of the extract on cellular immunity markers was obtained in rats by measuring white blood cells, CD4+ T lymphocytes, neutrophils, and total lymphocytes. The absolute counts of these cells were determined by flow cytometry phenotyping. This study showed that the ethanolic extract of Gomphrena celosioides significantly increases the number of white blood cells, neutrophils and CD4+ T lymphocytes, thus suggesting an immunostimulatory action of this extract in rats. Keywords: Gomphrena celosioides, ethanolic extract, acute toxicity, cellular immunity markers, immunostimulant

ABSTRACTPavetta corymbosa (Rubiaceae) is a plant traditionally used in sub-Saharan Africa for the treatment of pathologies such as malaria, pain, diabetes, hemorrhages, bacterial infections and typhoid fever. However, there is no scientific information on its analgesic potential, hence the interest of this study which is to evaluate the analgesic potential of the leaves of this plant which would justify its use in traditional medicine. The analgesic effect of the aqueous and hydroethanolic extracts of Pavetta corymbosa at doses of 200 mg / kg of body weight was evaluated by the injection of acetic acid 1% to mice in comparison with paracetamol (reference analgesic) at a dose of 150 mg / kg. The results showed that aqueous and hydroethanolic extracts significantly reduced abdominal contortions in mice (p < 0.05). However, the analgesic effect of both types of extracts is comparable to that of paracetamol. Hence the interest in its use in traditional medicine against certain pathologies. Keywords: Pavetta corymbosa, analgesic, aqueous extract, hydroethanolic extract.