analgesic

ABSTRACTPavetta corymbosa (Rubiaceae) is a plant traditionally used in sub-Saharan Africa for the treatment of pathologies such as malaria, pain, diabetes, hemorrhages, bacterial infections and typhoid fever. However, there is no scientific information on its analgesic potential, hence the interest of this study which is to evaluate the analgesic potential of the leaves of this plant which would justify its use in traditional medicine. The analgesic effect of the aqueous and hydroethanolic extracts of Pavetta corymbosa at doses of 200 mg / kg of body weight was evaluated by the injection of acetic acid 1% to mice in comparison with paracetamol (reference analgesic) at a dose of 150 mg / kg. The results showed that aqueous and hydroethanolic extracts significantly reduced abdominal contortions in mice (p < 0.05). However, the analgesic effect of both types of extracts is comparable to that of paracetamol. Hence the interest in its use in traditional medicine against certain pathologies. Keywords: Pavetta corymbosa, analgesic, aqueous extract, hydroethanolic extract.

Clerodendrum splendens is a twining evergreen climber, commonly known as Bharangi. The shrub is native to tropical Western Africa, is commonly cultivated in gardens for its brilliant scarlet flower in many parts of India. Clerodendrum species are rich source of flavanoids and diterpenoids compounds hence plant extracts are traditionally used as antiasthmatic and anti-inflammatory. No scientific work is yet reported on Clerodendrum splendens, hence present work was undertaken to establish analagesic and anti-inflammatory potential of the stem, leaves and flower extracts. Stem, leaves and flowers of the plant was collected, authenticated, shade dried and extracted successively with various solvents. Analgesic activity was assessed by hot plate method and acetic acid induced writing test in swiss albino mice and anti inflammatory activity was assessed by carrageenan-induced hind paw edema method in rats at 50 mg/kg, i.p. dose. Ethyl acetate extract of leaves showed most significant analgesic and anti-inflammatory activity.