Manju Nagpal

Resveratrol is a polyphenol found in grapes and red wines. Interest in this polyphenol has increased due to its pharmacological cardio- and neuroprotective, chemopreventive, and antiaging effects, among others. Nevertheless, its pharmacokinetic properties are less favorable, since the compound has poor bioavailability, low water solubility, and is chemically unstable. To overcome these problems, we developed two novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance resveratrol’s oral bioavailability for further use in medicines, supplements, and nutraceuticals. Solid lipid nanoparticles (SLNs) and nano structured lipid carriers (NLCs) loaded with resveratrol were successfully produced by homogenization and ultrasonication technique. These were completely characterized for particle size, zeta potential, DSC and TEM, to evaluate the quality of the developed resveratrol-loaded nanoparticles. The in vitro release studies showed that both the nanosystems are highly stable system allowing sustained and controlled release after uptake.

The aim of present work was to develop fast dissolving tablets of Valsartan by direct compression method using different binders such as acacia, sucrose, starch, gelatin, hydroxypropyl methylcellulose (HPMC) H7509, and Polyvinyl-pyrrolidone (PVP). During the compression of tablets, binders keep the composition of these fast dissolving tablets together. The right selection of binder or combination of these is essential to maintain the integrity and stability of the tablet. The prepared tablets were evaluated for parameters such as hardness, friability, drug content, weight variation, wetting time, water absorption ratio, in-vitro disintegration time, in vitro dissolution studies and stability studies. The study reveals that formulations prepared by direct compression (F5) exhibits better dissolution (90.57%) with lowest disintegration time (40 seconds) containing sucrose as binding agent.