Disintegration

The aim of present work was to develop fast dissolving tablets of Valsartan by direct compression method using different binders such as acacia, sucrose, starch, gelatin, hydroxypropyl methylcellulose (HPMC) H7509, and Polyvinyl-pyrrolidone (PVP). During the compression of tablets, binders keep the composition of these fast dissolving tablets together. The right selection of binder or combination of these is essential to maintain the integrity and stability of the tablet. The prepared tablets were evaluated for parameters such as hardness, friability, drug content, weight variation, wetting time, water absorption ratio, in-vitro disintegration time, in vitro dissolution studies and stability studies. The study reveals that formulations prepared by direct compression (F5) exhibits better dissolution (90.57%) with lowest disintegration time (40 seconds) containing sucrose as binding agent.

Most popular drug delivery in current days was solid drug delivery system it was more suitable in term of manufacturing and testing.  In solid oral dosage forms different grade of filler, binder, disintegrating agent, sweetener, lubricant, glident are used, which play important role in tablet hardness, disintegration and dissolution. Filler, binder, and disintegrating agent, were found to influence tablet dissolution and disintegration, with the filler and disintegrating agent exerting the most significant influence. Slower dissolution was observed with increasing disintegration time when either the filler or the disintegrating agent was kept constant. Generic formulation cover app 90% of all over market. Lots of regulatory body was developed guidelines for industry to develop and testing prepared genric formulation. Generic formulation same in term of strength, shape, release rate, colour, etc. Lot of generic formulation in market for one molecule with same effect in term which show more significant in term of cost and availability.