Md. Habban Akhter

The poor solubility is major drawback in the path of oral bioavailability. The oral bioavailability now a day is being enhanced via different technology. In which formulation of self nanoemulsified system proved to be highly significant in terms of improving oral bioavailability. Self nanoemulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, surfactants, cosurfactants and solvents etc. Under gentle agitation in the intestinal tract this system forms fine oil-in water (o/w) microemulsion prior to absorption and thus dissolution are not a rate limiting step. The current review outlines current updates on self nanoemulsifying drug delivery system and in vitro in vivo correlation of Probucol. Many formulations based on lipid drug delivery was successfully marketed under the trade name of Neoral® (cyclosporine, Novartis), Ritonavir (Norvir®, Abbott laboratories), Fortovase (Saquinavir, Hoffmann‐La Roche lnc.), Agenerase (Amprenavir, GlaxoSmithKline), lipirex (Fenofibrate, Sanofi‐ Aventis).

The more compatible mode of dispensing lipid based drug delivery system (LBDDS) had consorted to capsule filling since few decades back. For this hard or soft capsules shell often suffice for early development process. However, on account of some physical challenges to the capsule shell, are less preferred. On the other hand tablets in particular are more convenient mode of drug delivery for patients. The techniques covered hereunder alleviate the metamorphous of liquid or semi-solid formulations into solid particles such as dry powders, granules or pellets in order to fill into capsules, sachets or compressed into single or multilayered tablets.