Pankaj Khuspe

ABSTRACTDrug therapeutic effectiveness depends upon the drug molecules solubility and the bioavailability of drug molecules. After oral administration of drug to give pharmacological response, solubility is crucial parameter for obtaining desired concentration of drug molecule in systemic circulation. In current scenario about 40% of the newly developed drug molecules is poorly water soluble. With rate of dissolution and pharmacokinetic parameters like, absorption, distribution and excretion of drug molecules depend upon its solubility. Depending upon solubility and permeability, drugs are classified into four basic classes of the biopharmaceutical classification system (BCS) classification. The problem of poor solubility are faced in the Class II and Class IV of the biopharmaceutical classification system which comprises of novel generation of most all category of drugs like NSAIDs like Zaltoprofen,; anti-diabetics Gliclazide; newer calcium channel blockers like Nimodipine,. Till date various methods of ameliorating the solubility has been discovered and utilized successfully to enhance the solubility. This review highlights briefly on information about important approaches of novel solubility enhancement techniques.Keywords: Solubility enhancement, Cryo-technology, Sono-crstallization