Renu Solanki

Wounds are major responsible for physical disabilities. Wound disease spread by the invasion of bacteria inside the body through skin. Most of pathogenic microorganisms responsible for wound include Staphylococcus aureus, Streptococcus pyogenes, Enterococci, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Bacterial infections on skin are the common ailment for generation of other diseases in the body. Wound infections represent the invasion of tissues by number of species of microorganisms. These infections disturb the immune system of body and cause delayed wound healing. Aloe vera leaves pulp is used for medicinal purposes, including treatment of constipation, asthma, diabetes, peptic ulcer, inflammation, wound healing, heart burn, heat stroke etc. While Azadirachta indica is useful in tiredness, cough, fever, loss of appetite, worm infestation. It heals wound, heat-rash, boils, jaundice, leprosy, skin disorders, eye disorders, stomach ulcers, chicken pox, excessive thirst, diabetes and insect poisons. It act as anti-leprotic, antimalarial, anti-hemorrhoidal and anthelmintic agent. The present study was undertaken on evaluation of combinational effect of ethanolic extract of Aloe vera leaves pulp and Azadirachta indica leaves for wound healing activity through topical route on excision wound model. The activity was compared with standard drug Povidone Iodine ointment(5% w/w). Combinational effect of both extract was showed faster wound healing effect than standard drug Povidone Iodine ointment on excision wound model.

Pain is defined by the International Association for the Study of Pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Pain has now been equated to a fifth vital sign highlighting the significance of pain management in patient care. Tramadol is a centrally acting analgesic which is structurally related to codeine and morphine. It is effectively used to treat moderate to severe acute and chronic pain in diverse conditions. Tramadol is placed on the second step of WHO analgesic ladder and in contrast to traditional opioids, exerts its analgesic activity, a dual mechanism of action inhibiting transmission as well as perception of pain. Tramadol is more suitable than NSAID’s and coxib’s for patient with GI, renal and cardiovascular problems. Combined with low dependence/abuse potential, it has proven to be of significant advantage over other agents especially in the elderly.

Most of skin diseases are caused by pathogenic microorganisms which include Staphylococcus aureus, Streptococcus pyogenes, Enterococci, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Wounds are major responsible for physical disabilities. Wound disease spread by the invasion of bacteria inside the body through skin. Bacterial infections on skin are the common ailment for generation of other diseases in the body. Wound infections represent the invasion of tissues by number of species of microorganisms. These infections disturb the body immune system and cause inflammation, tissue damage and delayed wound healing process. Rhizomes of Curcuma longa (Turmeric) and leaves of Azadirachta indica (Neem) are used for various medicinal purposes. Curcuma longa possesses antibacterial, anti-inflammatory, anti-arthritic, anti-hepatotoxic and anti-allergic properties. Ayurvedic texts described it to be good for skin ailments and also as a blood purifier, wound cleanser, healer, remover of body toxins, killer of abdominal worms and a wind-repellent agent etc. While Azadirachta indica is useful in tiredness, cough, fever, loss of appetite, worm infestation. It heals wound, heat-rash, boils, jaundice, leprosy, skin disorders, eye disorders, stomach ulcers, chicken pox, excessive thirst, diabetes and insect poisons. It act as anti-leprotic, antimalarial, anti-hemorrhoidal and anthelmintic agent. The present study was undertaken on evaluation of combinational effect of ethanolic extract of Curcuma longa rhizomes and Azadirachta indica leaves for wound healing activity through topical route on excision wound model. The activity was compared with standard drug Povidone Iodine ointment (5% w/w). Combinational effect of both rhizomes and leaves ethanolic extract was found to have better and faster wound healing effect than standard drug Povidone Iodine ointment on excision wound model.