Senthilkumar K

ABSTRACTIn 1947, the Zika virus, a mosquito-borne flavivirus, was identified in Uganda. This virus was later placed in the monkey and spread worldwide to the human population. But still, particular medicine and treatment are not available. Common antiviral synthetic drugs, such as sofosbuvir, boceprevir, etc., produce more side effects. To overcome this problem, we move on to alternative medications. In this study, the medicinal plant Acorus calamus had antiviral activity. It belongs to the family of Acoraceae. In ancient times Acorus calamus was widely used in traditional therapeutic systems. The rapidly developing field of Molecular Docking study approach predicts the plant Acorus calamus phytoconstituents against the Zika virus. In this study, we determine the novel potential active principle to inhibit the Zika virus's extension using molecular modelling using the Schrodinger Maestro 12.7 version. Qikprop tool also performs ADME screening. We have taken 60 phytochemicals from the Acorus calamus plant. The top-hit phytoconstituent of Galangin shows a high docking score compared to other phytoconstituents. The drug-likeness property of the Galangin obeyed in all parameters. The docking score of Galangin (-7.391kcal/mol) is higher than the reference drug sofosbuvir (-5.5 kcal/mol). The results reveal that Galangin could benefit as the lead drug candidate for inhibitors for the Zika virus. Keywords: Acours calamus, Zika virus, Molecular Docking, Maestro and NS5BPolymerase.

ABSTRACTPantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach mainly used to treat erosive esophagitis and other condition involving excess stomach acid such as Zollinger-Ellison syndrome. The objective of present study was to Formulate and Evaluate fast dissolving tablets of Pantoprazole sodium. In the preformulation study, IR Spectra of pure drug and with different polymers showed no interaction (no shift in peak). To enhance faster disintegration rate, super disintigrants such as croscarmallose sodium, Crospovidone and Sodium starch glycolate were tried. To evaluate their role in fast dispersion, they were used in different concentrations hence in the present study 9 formulations were prepared. The prepared tablets were subjected to various parameters like uniformity of weight, hardness, friability, drug content, water absorption ratio, wetting time, in vitro disintegration time and in vitro dissolution studies. The effect of different super disintigrants over the Drug release profile was investigated. In the study, all powder blends showed good flow ability (angle of repose below 30º), bulk density in the range between 0.33-0.37 g/cm3 tapped density in the range between 0.34 and 0.39 g/cm3, and the compressibility index was found to be between 5.83 and 9.98 %, which ensures the blend that may be suitable for direct compression in to tablets. In vitro disintegration time for all formulation batches i.e. F-1 to F-9 showed wide variation in the range between 8.78.64 to 19.35 seconds and % Drug dissolved at 30 seconds. The prepared tablets exhibited satisfactory physico-chemical characteristics. The prepared formulations containing superdisintegrants, Crospovidone Along with microcrystalline cellulose showed faster dispersion and dissolution profile as compared with other two superdisintegrants containing formulations. Moreover, the  study revealed Crospovidone showed satisfactory results than the superdisintegrants like c