in-vitro drug release.

ABSTRACTThe main aim of the study was to design Perphenazine solid lipid nanoparticles and to evaluate them. The Perphenazine solid lipid nanoparticles were prepared by the hot homogenization followed by ultrasonication method by using the different lipids (Tristearin, GMS, Compritol) Soya lecithin as stabilizer and Tween-80 used as surfactant. The FTIR test is conducted as the preliminary test, by this test there was no interaction between the drug and lipids. Then nanoparticles were evaluated for particle size, PDI, zeta potential, entrapment efficiency and in-vitro drug release. The particle size ranged from 53.46 to 518.6 d.nm, PDI ranged from 0.284 to 0.502, zeta potential from -9.83 to -40.96 mV and entrapment efficiency was ranged from 77.45 to 95.38%.The cumulative percentage release from all SLNs varied from 53.35 to 88.74 % after 24hours depending upon the drug and lipid ratio and F2 formulation showed highest drug release i.e., 88.74%. The release kinetic studies showed that the release first order diffusion controlled and the n value (0.47) from the Korsmeyer-Peppa’s model indicated the release mechanism was Quasi-fickian type. Keywords: Perphenazine, Solid lipid nanoparticles, FTIR, in-vitro drug release.

ABSTRACTPantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach mainly used to treat erosive esophagitis and other condition involving excess stomach acid such as Zollinger-Ellison syndrome. The objective of present study was to Formulate and Evaluate fast dissolving tablets of Pantoprazole sodium. In the preformulation study, IR Spectra of pure drug and with different polymers showed no interaction (no shift in peak). To enhance faster disintegration rate, super disintigrants such as croscarmallose sodium, Crospovidone and Sodium starch glycolate were tried. To evaluate their role in fast dispersion, they were used in different concentrations hence in the present study 9 formulations were prepared. The prepared tablets were subjected to various parameters like uniformity of weight, hardness, friability, drug content, water absorption ratio, wetting time, in vitro disintegration time and in vitro dissolution studies. The effect of different super disintigrants over the Drug release profile was investigated. In the study, all powder blends showed good flow ability (angle of repose below 30º), bulk density in the range between 0.33-0.37 g/cm3 tapped density in the range between 0.34 and 0.39 g/cm3, and the compressibility index was found to be between 5.83 and 9.98 %, which ensures the blend that may be suitable for direct compression in to tablets. In vitro disintegration time for all formulation batches i.e. F-1 to F-9 showed wide variation in the range between 8.78.64 to 19.35 seconds and % Drug dissolved at 30 seconds. The prepared tablets exhibited satisfactory physico-chemical characteristics. The prepared formulations containing superdisintegrants, Crospovidone Along with microcrystalline cellulose showed faster dispersion and dissolution profile as compared with other two superdisintegrants containing formulations. Moreover, the  study revealed Crospovidone showed satisfactory results than the superdisintegrants like c