Sudheer Challa

Two simple, sensitive selective accurate and economical spectrophotometric methods (Method-A&B) for the determination of Nateglinide in bulk drug and pharmaceutical formulations (tablets) have been described in the present work. Method - A is based on the formation of orange red colored ion-association complex between Nateglinide and Tropaeolineooo (TPooo) exhibiting absorption maximum at 470nm and obeying Beer’s law in the concentration range of 2.5-12.5µg/ml. The Method - B is based on the formation of Ion-association complex between Nateglinide and Alizarine Red S (ARS) to yield an yellow colored chromogen exhibiting absorption maximum at 440nm (Method B) and obeying Beer’s law in the concentration range of 2.5-12.5µg/ml. Statistical analysis of the results has been carried out for the proposed methods revealing high accuracy and good precision. The proposed methods developed by the author could be successfully extended to the commercial pharmaceutical formulations (tablets) containing Nateglinide.