Sukhen Som

Benzimidazole derivatives play an important role in medicinal field with many biological and pharmacological activities related to it. Extensive biochemical and pharmacological studies have confirmed that the potency of these clinically useful drugs in treatment of microbial infections is encouraging and inspiring for further development of some more potent and significant compounds. A series of benzopyrone substituted benzimidazole derivatives were synthesized by reacting benzopyrone-3-carboxylic acid with o-phenylene diamine. The analogues were synthesized in a good yield. The structural characterizations for derivatives were carried out by IR, 1HNMR and Mass spectral studies. The compounds were subjected for antibacterial screening, among them 4c and 4i showed appreciable activity against all the strains. It can be concluded from the antibacterial study that the derivatives may be proved useful for future development.

As many scientific and technical observations are pouring informations about the activity and effectiveness of synthetic and semi synthetic derivatives related to quinolines and benzimidazoles it was concern to explore this two leads in a single molecular entity.  The present study embodied the synthesis and evaluation of antibacterial activity of a series of benzimidazole substituted quinoline derivatives condensed with different amines. The derivatives were synthesized in moderate to good yields. The characterizations for the synthesized derivatives were done by IR, 1H NMR and Mass spectral analysis. The compounds were then subjected for antibacterial screening, among them 4c and 4d showed appreciable activity against all the strains used. In the light of the results obtained from antibacterial studies, these derivatives can be further thoroughly investigated for future prospect.

Considering the potential to be a lead molecule and having a wide variety of pharmacological activities like anti-inflammatory, anticancer, antihepatotoxic, antibacterial, antiviral etc., a series of bioactive γ-benzopyrone compounds were synthesized and analgesic activity was evaluated. The synthesized compounds were characterized by IR, 1H NMR and Mass spectral studies. Some of the compounds synthesized i.e. 4c, 4d, 4g and 4h showed appreciable analgesic activity.