Alloxan induced diabetis

This  study  was  conducted to  investigate the   anti- diabetic effect of ethnolic extract of  Ochna obtusata leaves in Alloxan induced diabetic Wistar albino rats. The anti-diabetic activity was assessed by determining and comparing the fasted blood glucose level in the test group (200,400 mg/kg) with that of the diabetic control group and glibenclamide 20mg/kg was used as a reference standard. In the alloxan-induced diabetic rats Ochna obtusata produced a significant reduction in fasting blood glucose levels. It acts in a dose dependant manner to bring back the raised blood sugar levels to normal. The 400mg/kg treated group has showed maximum reduction  in blood glucose (148.26 mg/dl) which is closer to that of standard Glibenclamide (145.71 mg/dl). We can conclude that  ethnolic extract of  Ochna obtusata is capable of managing hyperglycemia induced by alloxan. The extract seems to be  one of the potential sources  for the development of a novel phytotherapy for diabetes mellitus.