BP

ABSTRACTGossypin (3,5,7,3,4-pentahydroxy-8-o-glucoside) a bioflavonoid was  evaluated for protection against  L-NAME(L-NG-Nitroarginine methylester) induced hypertension in albino rats, based on its effects on body weight of animals and arterial blood pressure. Male adult albino rats (220-2600gm)were used in this study. The hypertensive activity was measured using AD 8 channel Lab chart solution instrument. The activity was carried out in acute and chronic models .In acute studies animals were divided into 5 equal groups of five rats each. group I was the normal group received normal saline and group II as control group received L-NAME (20mg/kg i.v after 30 minutes of arterial cannulation .Group III as standard received losartan (10 mg/kg b.w.i.v) after increase in B.P produced by L-NAME while group IV, V. received gossypin at a dose of 5,10, mg/kg b.w i.p after inducing hypertension. In chronic studies animals were divided into 6 equal groups of 6 animals each. Group I normal group received normal saline orally for 4wks and group II received L-NAME (40mg/kg p.o )for 4 wks Group III as STD group received losartan (20mg/kg p.o) while group IV.V.VI  as treated groups received Gossypin( 5,10,20,mg/kg b.w p.o)for 4 wks. After last dose the animals were examined for weight variation and B.P determination by invasive method using AD instrument. The left carotid artery was cannulated for B.P measurement and femoral vein for drug administration. The hypertension induced   by  L-NAME  was  indicated  by  elevated  levels in systolic B.P and decrease in body weight of animals. In acute hypertension, L-NAME increases systolic B.P and mean B.P and decrease in heart rate which was administrated through carotid artery after 30 mins of stabilization of B.P.  There was increase in systolic and mean B.P and decrease in heart rate. The drug was administered by I.P shows significant reduction in elevated b.p which was observed for 2hrs.In chronic hypertension L-NAME induced group show

Today time is the time of digital technology .people accomplished many wonderful things when they get themselves connected to each other and it mostly happens due to the use of mobile phone .but excessive use of mobile phone can affect our health by damaging our body immune system, blood particle and its density, deformability of red blood cell, reproductive system, brain cell, changes neuronal activity .Radio frequency electromagnetic fields (RFEMF) produced by mobile phone is lethal to body because 70% of human body is made of water and due to watery composition of our body the radiation is absorbed in human body and sometime also cause cancer. But this can be protected partially by natural electromagnetic bead known as Rudraksha. Rudraksha are nothing but the seeds of the plant Elaeocarpus Ganitrus which is famous for its medicinal property from the ancient time. It is proven in modern scientific lab that this seed have definite electromagnetic property. In the present experimental study attempt has been made to show natural prevention technique of harmful radiations of mobile phone by the help of Elaeocarpus Ganitrus seed Rudraksha.