COVID-19

ABSTRACTThe COVID-19 pandemic had a severe global impact. A range of campaigns and activities, including vaccines, are being implemented to counteract this pandemic. Using observational data, the goal of this scoping review is to identify adverse events connected with COVID-19 vaccinations. We conduct a scoping study and searched three databases from the start of the COVID-19 pandemic in 2020 through June 2022. Based on our criteria and searched keywords, the review included eleven papers in total, with the majority of the studies being conducted in developed countries. The study populations varied and included general community populations, healthcare professionals, military forces, and patients with systemic lupus and cancer. This study includes vaccines from Pfizer-BioNTech, Oxford-AstraZeneca, Sinopharm, and Moderna. The COVID-19 vaccine-related adverse events were classified into three types: local side effects, systemic side effects, and other side effects such as allergies. The adverse reactions to COVID-19 vaccines are mild to moderate in severity, with no significant influence or interference in individual daily activities and no unique patterns in cause of death among vaccine-related deaths. According to the findings of these investigations, the COVID-19 vaccine is safe to administer and induces protection. It is vital to convey accurate information to the public about vaccination side effects, potential adverse responses, and the safety level of the vaccines supplied. Multiple strategies must be implemented at the individual, organizational, and population levels to eliminate vaccine hesitance. Future studies could investigate the vaccine’s effect on people of various ages and medical conditions. Keywords: COVID-19, vaccination, immune system, blood cells

ABSTRACTHydroxychloroquine is used in the treatment of malaria due to its pharmacological activity and with minimal adverse effects. Hydroxychloroquine is used in treatment of the diseases like rheumatoid arthritis and lupus erythematosus. In some countries, it is also indicated in the prevention or treatment of malaria. It has been developed in the 1950s from chloroquine, an old anti-malarial drug. COVID-19 is a highly contagious disease, transmitted through respiratory droplets by affected person through sneezing, coughing, talking, which also spread by touching a contaminated surface or may object. The person infected with the disease shows flu-like symptoms such as fever, muscle pain, cough and sore throat in five to six days after infection, while some patients may remain asymptomatic carriers. The disease further develops severe pneumonia in the patients. The mortality rate is high in patients with underlying conditions and those aged 60 years and above. This review complies about the mechanism, precautions, toxicity, ongoing trials of hydroxychloroquine and their medicinal usage. Keywords: Chloroquine, Clinical trials, COVID-19, Hydroxychloroquine.