Captopril

In the present investigation, an attempt has been made to increase therapeutics efficacy, reduce frequency of administration and improve patient compliance by developing sustained release gastro retentive floating tablets of Captopril using hydrocolloids like hydroxy propyl methylcellulose and Carbopol 934P by effervescent technique using direct compression method. In tablets formulations sodium bicarbonate and citric acid using gas generating agent and HPMC different grade was used to retard the drug release for 24 hrs in stomach. The prepared Gas powered tablets were subjected to post-compressional parameters. Drug compatibility with excipients was checked by DSC and FTIR studies. The stability study conducted 3 months as per the ICH guidelines. In all the formulations, hardness test indicated good mechanical strength, friability is less than 1% indicated that tablets had a good mechanical resistance. The results were revealed that as concentration of HPMC increases there is increase in floating time but release of the drug from all the formulation shows the slow release of Drug, as the concentration of sodium bicarbonate increases there is quick release of drug from all the formulation but the floating time decreases as the concentration of sodium bicarbonate increases so the optimum concentration of HPMC and Sodium bicarbonate is essential in order to achieve good result with respect to both drug release as well as floating time and floating lag time. It has been concluded that Formulation F1 and F4are the excellent formulation as they shows excellent drug release for 24 hrs with minimum floating lag time and more total floating time.