Complexation

Cyclodextrins are non-toxic cyclic polysaccharides. They form inclusion complexes with numerous organic molecules. The physical and chemical properties of the guest molecules change due to complex formation. Cyclodextrins (CDs) are chemically cyclic oligosaccharides which have been recognized as useful pharmaceutical excipients. Cyclodextrins are versatile pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drug. Besides, being used to reduce gastrointestinal drug irritation, convert liquid drug into microcrystalline or amorphous powder, and prevent drug-drug and drug-excipients interactions. The solubility of slightly soluble molecules may be increased by cyclodextrin inclusion complex. As a result of molecular complexation phenomena cyclodextrins are widely used in many industrial products, technologies and analytical methods.