Fourier-transform infrared spectroscopy

ABSTRACTThe oral dissolving tablets is defined as one, which has drug in it and when placed on tongue dissolves completely within a limited span of time, without additional requirement of water. Drug is released, dispersed in the saliva and swallowed and subsequently absorbed in the gastrointestinal tract (GIT). To achieve quick disintegration in oral solid dosage forms, it’s important to have high porosity in the tablets. This allows faster penetration of water and thus accelerates the disintegration. Oral dissolving tablets are the preferred means for patients with oral disorders and patients with dysphagia. It could also be friendly, with geriatric, paediatric and mentally challenged people. Oral dissolving tablet formulation are made by many techniques but in this study, we have made BARETab® ODT quick dissolving matrix using spray drier, characterized by Fourier-transform infrared spectroscopy and melting point test, morphology studied by scanning electron microscope, evaluation done with physicochemical test such as bulk density, flowability, average particle size distribution, compressibility index, water content and residue on ignition. Ondansetron oral dissolving tablet was thereafter made using with BARETab® ODT quick dissolving matrix. Ondansetron oral dissolving tablet was evaluated by in-vitro testing such as physical evaluation, weight uniformity, hardness, friability, disintegration and drug released profile. BARETab® ODT quick dissolving matrix have very good morphology, every particle contains binder, filler, glidant, sweetener and super disintegrant. It has outstanding physiochemical properties which helped to deliver good quality Ondansetron tablet. It has less friability, satisfactory hardness and quick disintegration time. Keywords: Orally Disintegrating Tablets, Fourier-transform infrared spectroscopy, melting point, Scanning electron microscope, In-Vitro Disintegration Time