NSAIDs

NSAIDs remains as a major choice for analgesis (pain-killing), antipyretic (fever-reducing) and in higher doses as an anti-inflammatory  agent in orthopaedics. The objective of the present study was to conduct a prospective observational study to collect data’s of patients those who were admitted in orthopedic department and thereby have assessment on the usage of NSAIDs and gastroprotective agents. A total of 68 subjects were included in the study, 57.35% (n=39) were male and 42.6% (n=29) were female. Maximum number of patients who received NSAIDs were in age group of 41-50 i.e.,26.4% (n=18), followed by 20.50% (n=14) 31-40 age group and 16.1% (n=11) were in between 51-60 age group. Only 8.8% (n=6) of patients were above 70 years of age and prescribed with NSAIDs. NSAIDs were mainly prescribed as the supportive treatment of fracture 41.1% (n=28) followed by Spondylosis 26.4% (n=18), Osteoarthritis 13.2% (n=9) and Joint dislocation 11.7% (n=8) etc. Diclofenac 75% (n=51) was found to be the commonly prescribed NSAIDs followed by Piroxicam 16.1% (n=11), whereas the least prescribed NSAIDs was found to be Etoxicoxib 2.9% (n=2). The result revealed that 51.4% (n=35) of the patients underwent Dual therapy followed by 48.5% (n=33) with Monotherapy. In this study 76.4% (n=52) patients were prescribed with Parenteral NSAIDs whereas, 23.5% (n=16) patients with oral route of NSAIDs and 5.8% (n=4) with topical NSAIDs. Around 89.7 %(n=61)of patients were co-prescribed with gastroprotective agents (GPA). Pantoprazole and Rabeprazole were the most frequently prescribed GPA which were accounted by 38.2% (n=26) followed by Ranitidine 10.2% (n=7).67.2% (n=41) were administered in oral route followed by 32.7% (n=20) parent rally38.2% (n=26).

Antibiotics, analgesics and local anaesthesia are the frequently used drugs during the treatment of dental diseases. These drugs can interact to different drug classes used in different systemic conditions. Some of these interactions are adverse and life threatening to the patients. The dental practitioner should have thorough knowledge about these interactions and methods to prevent and treat the adverse effects. This article will discuss the common possible drug interactions and their adverse effects in clinical dental practice.