Paracetamol

The present study was conducted to evaluate the hepatoprotective activity of Ethanolic extract of Sechium edule against paracetamol induced liver damage in rats. The Ethanolic extract of Sechium edule (300mg/kg & 600mg/kg) was administered orally to the animals with hepatotoxicity induced by single dose of Paracetamol (2gm/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose (CMC) solution. The Ethanolic extract of leaves of plant Sechium edule in the doses of 300mg/kg, 600mg/kg body wt, reduced the levels of serum SGPT, SGOT, ALP and Total bilirubin and increased the Total protein level significantly. In the histopathological studies of the liver section of rats showed the significant recovery with the Ethanolic extract of Sechium edule when compared with Control group and Paracetamol treated group.

The objective of the study of antipyretic effect of ethanolic extract of flowers of Artabotrys hexapetallus tested on yeast induced pyrexia in albino rats. The flower extract at oral doses of 100, 250 and 500 mg/kg has been used to investigate the antipyretic potential of flowers extract. At a dose of 500 mg/kg body weight showed significant reduction in body temperature on yeast induced pyrexia when compared to standard drug Paracetamol (200 mg/ml).