osteoporosis

Main objective and aim of prospective, cross sectional research is to evaluate the magnitude of applicability of International Osteoporosis Foundation Guidelines for diagnosis, prevention and treatment of Osteoporosis in Asia for Pakistani population. Study was conducted during December 2015 to January 2017 in Karachi, Pakistan. Primary data has been collected from 30 internists working in private and government sector hospitals and clinics. Six main domains scope and purpose, stakeholder involvement, rigour of development, clarity of presentation, applicability, editorial independence and overall quality of IOF guide for Asia are evaluated. Data was analyzed through SPSS 20 by using descriptive statistics. Among 30 internists, number of practitioners from hospital (57%), clinic (43%), private sector (73%), government sector (27%). Magnitudes of six domains are scope and purpose 71%, stakeholder involvement 62%, rigour of development 86%, clarity of presentation 88%, applicability 85%, and editorial independence 74%, all these domains are significantly (p

Osteoporosis is a rising threat for wide-reaching inhabitants, to treat this calcium supplements are suggested but available option of calcium supplements are not satisfying the need of the therapies, nor the patients’ acceptability. To explore traditional system of medicine in osteoporosis, concept of bhasma was opted for the study. Preparing bhasma with traditional method is a stepwise and complex process, hence to check any alteration is possible or not; preparing bhasma in electrical muffle furnace is tried out. Prepared bhasmas were evaluated by different parameters (varna, varitara, rekhapurana, nischandra) mentioned in Ayurveda literature and few modern parameters (ash value, pH, LOD, NPST, XRD, particle size, calcium content).  These evaluation parameters give a scientific background to bhasma as nanomedicine that could be better absorbed in the body. To overcome the problem related to organoleptic properties (taste, appearance), delivering bhasma in chocolate base was attempted and this chocolate dosage form were evaluated by for its patients’ acceptability. Findings of the study reveals that chocolate could serve as a patient friendly dosage form to deliver bhasma as a source of calcium.

Osteoporosis is a disease where reduced bone strength enhances the risk of a broken bone. It is the most common cause for a broken bone among the elderly. Bones that are commonly break include the bones of the forearm, the back bones, and the hip. Until a broken bone happens  there are typically no symptoms. Bones may weaken to  a degree that a break may occur with minor stress or spontaneously. Cronic pain and a reduced ability to accomplish normal activities may occur following a broken bone.  The aim of this study was to assess the efficacy of simvastatin in treatment of postmenopausal women with osteoporosis and compare it's effect with calcium plus vitamin D3 . Twenty four postmenopausal women with osteoporosis were randomly divided into two groups( each group include twelve women) , in addition to apparently healthy group include twelve postmenopausal women without osteoporosis considered as a control group .The duration of treatment was 6 months . First group was given simvastatin tablet 20mg once daily, second group was given calcium plus vitamin D3(calcium 600mg plus vitamin D3 500 I.U.) once daily .The following parameters were measured for two groups at baseline and at 6 months intervals bone mineral density(BMD) and T-score , total cholesterol , and triglyceride . There were a significant increase in BMD, T- score in group treated with simvastatin after 6 months as compared with baseline and with group treated with calcium plus vitamin D3 . Also there were a significant reduction in mean serum total cholesterol and triglyceride in group treated with simvastatin e and group treated with calcium with vitamin D3 after six months as compared with baseline(P