Protective Effects of Some Antioxidants on Mosquito Repellent (Bioallethrin)-Induced Toxicity in Infant Rats

The aim of the present study was to investigate the potential toxic effects of bioallethrin-based Mosquito-Repellents (MR) in non-adult rats as well as to ascertain whether the antioxidant substances such as Vitamin C and Vitamin E + Selenium  have any roles in preventing such toxic effects or not. 100 rat pups were divided into four study groups (each group consists of 25 rat pups) as Group I (control), Group II (bioallethrin), Group III (Vit C+ bioallethrin) and Group IV (Vit E+selenium+bioallethrin).  The animals in Group II, III, IV were exposed to the vapor of heated tablets including 4.2% bioallethrin 8 hours/day for a period of ninety days in a room with a volume of 23 m3. Vit C was added at a concentration of 500 mg/L to the fresh drinking water of animals in Group III. Vit E+Selenium combination was administered intraperitonally to the animals in Group IV once weekly at a dose of 50 mg/kg. According to the results, it was determined that antioxidants, particularly combination of Vitamin E+selenium administration, may be beneficial at preventing toxic effects of bioalletrin in rat pups. As a conclusion, when bioallethrin based- MR is used, Vit E+Selenium combination can be advised to prevent the effects of bioallethrin.