Formulation and Evaluation of Phytosomes of Thalictrum foliolosum leaves extract

ABSTRACTPhytosome is a nanovesicle that combines plant extracts and phospholipids to produce more soluble fat complex and provide better absorption. Thalictrum foliolosum DC is widely distributed plant in the Himalayan region extending India, Nepal, Bhutan, South East Tibet and Burma between an altitude range of 1000-3400?m. Within India, it was recorded in Jammu & Kashmir, Himachal Pradesh, Punjab, Uttar Pradesh, Delhi, Sikkim, Arunachal Pradesh, Meghalaya, Bihar, Orissa, Andhra Pradesh and Tamil Nadu. In traditional medicine, various parts of this plant, including its bark, stems, and leaves, have been employed to address a range of health concerns, such as malaria, cancer, mental disorders, and pain relief. In the current days, the majority of the widespread diseases and nutritional disorders are treated with natural medicines. The efficiency of any herbal medication is reliant on the delivery of efficient level of the therapeutically active compound. But a harsh limitation exists in their bioavailability when administered orally or by topical applications. Phytosomes are lately introduced herbal formulations that are superior absorbed and as a result produced superior bioavailability and actions than the conformist phyto molecules or botanical extracts. The ethanolic extract of phytosome was prepared in soya lecithin. Soya lecithin has antioxidant activity. Evaluation of phytosomes for solubility study, entrapment efficiency, transition temperature, particle size and size distribution, optical microscopic study, zeta potential. The results showed the formation of a stable formulation with molecular interaction between the extract and phospholipids. The drug release from the phytosomes was sustained and showed significant improvement compared to the conventional extract. Keywords: Phytosome, phospholipids, Thalictrum foliolosum, entrapment efficiency, etc.