entrapment efficiency

ABSTRACTPhytosome is a nanovesicle that combines plant extracts and phospholipids to produce more soluble fat complex and provide better absorption. Thalictrum foliolosum DC is widely distributed plant in the Himalayan region extending India, Nepal, Bhutan, South East Tibet and Burma between an altitude range of 1000-3400?m. Within India, it was recorded in Jammu & Kashmir, Himachal Pradesh, Punjab, Uttar Pradesh, Delhi, Sikkim, Arunachal Pradesh, Meghalaya, Bihar, Orissa, Andhra Pradesh and Tamil Nadu. In traditional medicine, various parts of this plant, including its bark, stems, and leaves, have been employed to address a range of health concerns, such as malaria, cancer, mental disorders, and pain relief. In the current days, the majority of the widespread diseases and nutritional disorders are treated with natural medicines. The efficiency of any herbal medication is reliant on the delivery of efficient level of the therapeutically active compound. But a harsh limitation exists in their bioavailability when administered orally or by topical applications. Phytosomes are lately introduced herbal formulations that are superior absorbed and as a result produced superior bioavailability and actions than the conformist phyto molecules or botanical extracts. The ethanolic extract of phytosome was prepared in soya lecithin. Soya lecithin has antioxidant activity. Evaluation of phytosomes for solubility study, entrapment efficiency, transition temperature, particle size and size distribution, optical microscopic study, zeta potential. The results showed the formation of a stable formulation with molecular interaction between the extract and phospholipids. The drug release from the phytosomes was sustained and showed significant improvement compared to the conventional extract. Keywords: Phytosome, phospholipids, Thalictrum foliolosum, entrapment efficiency, etc. 

The objective of the current study was to design and optimize Etodolac loaded Eudragit RS 100 microcapsules using solvent evaporation method. Quality by design approach was implemented for development of Etodolac microcapsules using I-Optimal RSM design. Based on initial risk assessment and preliminary study, two independent variables, Drug: Eudragit RS 100 ratio and stirring speed were selected for Design of Experimentation (DoE) to see effect on critical quality attributes (CQAs); entrapment efficiency and particle size. The prepared Etodolac loaded Eudragit RS 100 microcapsules were characterized for particle size, entrapment efficiency, in-vitro dissolution study, DSC, XRD and SEM. Acceptance criteria for CQAs were considered as particle size in the range of 22-200 µm and entrapment efficiency in the range of 72.86-97.25 %, which generated the design space with combination of selected critical parameters leading to the acceptable operating ranges for formulating microcapsules with respect to desired Target Quality Product Profile (TQPP). The obtained Etodolac loaded Eudragit RS 100 microcapsules were spherical in shape, having better entrapment efficiency and sustained drug release profile. Validation of model was carried out by comparing experimental values with predicted value of optimized formulation. Optimized formulations within design space were capable of sustaining drug release for about 22 hours and were expected to reduce dosing frequency thus reducing side effects associated with therapy.