Spectrophotometric Determination of Ferophenem Drug and Commercial Pharmaceutical Formulation

Two simple, sensitive selective accurate and economical spectrophotometric methods Method A&B for the determination of feropenem in bulk drug and pharmaceutical formulations (tablets) have been described in the present work. Method - A is based on the formation of  red colored ion-association complex between feropenem and methiline blue (MB) exhibiting absorption maximum at 650nm and obeying Beer’s law in the concentration range of 4-20µg/ml. The Method - B is based on the formation of Ion-association complex between feropenem and safranine-o(SFO) to yield an yellow colored chromogen exhibiting absorption maximum at 520nm(Method B) and obeying Beer’s law in the concentration range of 4-20µg/ml. Statistical analysis of the results has been carried out for the proposed methods revealing high accuracy and good precision. The proposed methods developed by the author could be successfully extended to the commercial pharmaceutical formulations (tablets) containing feropenem.