Dissolution Enhancement of Domperidone Maleate by Preparing Fast Dissolving Tablets Using Liquisolid Compact Technique

Domperidone maleate is dopamine receptor blocking agent and first choice drug in antiemetic category. Major drawback of this drug is its very low water solubility and low erratic absorption from gastrointestinal tract. The purpose of present investigation was to increase the solubility and dissolution rate of Domperidone maleate by preparation of liquisolid compacts and preparation of fast dissolving tablets by direct compression method. Superdisinegrants used were Crospovidone, Croscarmellose Sodium and Sodium Starch glycolate. Propylene glycol, Polyethylene glycol 200, Polyethylene glycol 400 was used as a liquid vehicle and Avicel-PH 102, Aerosil-200 as a carrier and coating material respectively. Tablets were prepared and evaluated for various parameters like hardness, thickness, friability, weight variation, wetting time, in-vitro disintegration time, in-vitro dispersion time, in-vitro dissolution study. Formulation F13 showed 95.5 % drug release within 30 min. It was inferred that liquisolid compact technique is useful in enhancement of dissolution rate and bioavailability of Domperidone maleate.