Formulation and Evaluation of Proniosomal Transdermal Gel of Drug Luliconazole

INTRODUCTION: Proniosomal gels are generally present in transparent, translucent or white semisolid gel texture, which makes them physically stable during storage and transport. Due to the limited solvent system present, the proniosomes formed were the mixture of many phases of liquid crystal, viz. lamellar, hexagonal and cubic phase liquid crystals as given in dissolution of most surfactants in water, leads to the formation of lipotropic liquid crystals rather than micelle solution. Lamellar phase shows sheets of surfactants arranged in bilayer form, whereas in hexagonal phase cylindrical units are packed in hexagonal fashion. Cubic phase consists of curved bio-continuous lipid bilayer extending in three dimensions, separating two congruent networks of water channels. These liquid crystals present an attractive appearance because of their, transparency and high viscosity, although in the beginning of its formation, a short range of less viscous compositions (so called liquid/gel compositions) appear in some cases. Addition of water leads to interaction between water and polar groups of the surfactant results in swelling of bilayers. When the concentration of solvent is increased above a limited value, the bilayer tends to form random spherical structures, i.e., multilamellar, multivesicular structures. When shaken with water i.e., the aqueous phase of water, complete hydration takes place leading to the formation of niosomes. The beauty of these proniosomes lies in their ability to rearrange as stable niosomal suspensions, on hydration with water.