B. Shivakumar

ABSTRACTAccording to WHO cardiovascular disease (CVD) is the major cause of death in the worldwide. In India too, it has gone through a drastic lifestyle modification from traditional to western one and adapting sedentary lifestyle, consequently prone the people for CVDs. The present study was undertaken to identify the high risk individuals for CVDs in the next 10 years by using the cardiovascular risk assessment tools such as FRS and SCORE and recommendation of lifestyle modification and initiation of pharmacotherapy. A prospective observational study was conducted in patients with all possible risk factors (age, sex, high blood pressure, high HDL, TC, Smoking, and Obesity) for CVD over a period of six month in a tertiary care hospital. A total numbers of patients selected for the study was 90 among, 49 were males and 41 were females. The patients were categorized in to different risk groups. According to FRS tool, 35.5% individuals were at high risk and with SCORE tool, it was 41.1%. Whereas 33.3% individual who were under the high risk for CVDs by both the tools. The individuals’ lies between mild to moderate risk for CVDs were recommended for lifestyle modification to attenuate the triggering risk factors. Whereas high risk individual by both the FRS and SCORE tools were recommended for lifestyle modification along with pharmacotherapy in order to keep the risk factors under control. Keywords: Cardiovascular diseases; Risk factors; Assessment tools; Primary prevention.

ABSTRACTA new series of 2-chloro-3-[3-(6-methyl-1H-benzimidazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl]quinoline (Va-k) have been synthesized by the reaction of 3-(2-chloroquinolin-3-yl)-1-(6-methyl-1H-benzimidazol-2-yl)prop-2-en-1-one (IVa-k) with hydrazine hydrate in ethanol and glacial acetic acid. The synthesized compounds were characterized by their IR, 1H NMR and Mass spectral studies. Further, compounds were screened for their antimicrobial activity by cup plate method, using Ciprofloxacin and Fluconazole as a standard drugs. Results of the activities reveal that, compound exhibited moderate to good antibacterial and antifungal activities. Keywords: 6-Methylbenzimidazoles, Chalcones, Pyrazolines, Antimicrobial activity.

2-amino-6-fluoro-7-chloro (1,3) benzothiazoles is treated with six different aldehydes to get six different Schiff’s base (Azomethine) in presence of ethanol and HCl, then all the Schiff’s bases are separately refluxed with thioglycolic acid in presence of the solvent dioxane and triturated with NaHCO3 solution, as six different parent compounds. The resulted six azomethine (Schiff’s base) are treated with chloro acetyl chloride, triethylamine in presence of dioxane results gives six different, the parent compounds were treated with various aromatic primary and secondary amines in presence of Dimethyl formamide (DMF) gives various derivatives. Further, they have been screened for their antimicrobial, antiinflammatory (in-vitro and in-vivo) anticonvulsant and anthelmintic activity by standard method. Keywords; Fluorine, Schiff’s base, Thiazolidinone and Azetidinone