Javed Ali

Various conventional dosage forms are available in the market of the plants boswellia and liquorice. The drawbacks associated with their conventional dosage forms which are fluctuation in drug blood level, patient’s inconvenience, poor patient compliance, increased chances of missing the dose of a drug high dose potency etc. can be solved by formulating sustained release formulations of  these herbal drugs. Different formulations of boswellia and liquorice sustained release tablets were formulated using wet granulation method. The tablets were subjected to physicochemical studies, in vitro drug release studies, kinetic modeling and stability studies to find out the best formulation. Drug content was carried out by HPLC fitted with a C18 column using UV detector. The in vitro release studies were conducted for 24h using USP type 2 apparatus. The dissolution profile comparison of the prepared batches was done. The dissolution data profile was fitted into zero order, first order, Higuchi and Korsemeyer-Peppas models to identify the pharmacokinetics and mechanism of drug release. In vivo anti-inflammatory effects of the optimized formulations were evaluated by carrageenan-induced hind paw edema method. The results of the accelerated stability study for six months revealed that storage conditions were not found to have made any significant changes. The release of formulation F-4 of boswellic acid and F-6 of liquorice was prolonged for 24h and once daily matrix tablet was formulated.

Role of Ghiza (Diet) in health and disease is accepted in Unani system of medicine since thousand years. Hippocrates (BC 460-370) elaborated the importance of Makul (diet) for healthy life according to age. This concept said that diet becomes Badal Ma Tahallul (wear of tear). It plays an important role in maintaining the harmony of Akhlat Arba (four humors). In the old age, one should be careful about schedule and quantity of Ghiza. Legend Unani philosophers and physicians had given attention towards its essentiality to save and promote the health of elders. They elaborated types and Mizaj (temprament), as well as quantity of Ghiza systematically. Unani scholars recommended specific diet in specific seasons, ages and in specific diseases. This review article aims at surveying the classical unani literature to explore the diet and its essentiality in elderly.

Qilatte Haiwane Manwiya (oligospermia) is one of the most common causes of male infertility. Despite up to date advances in the management of male infertility, the problem has not been solved satisfactorily. There are various defects in spermatozoa found on semen analysis which produce male infertility such as inadequate number of spermatozoa in semen, the failure of spermatozoa to move with adequate power and speed toward their target etc. Eminent Unani physician are treating the problem since the time immemorial not only for improving the numbers of spermatozoa but also the other defects of spermatozoa. In almost every Unani treatise, the discussion about Qilatte Haiwane Manwiya is found in detail including the causes, pathology, pathogenesis, clinical presentation, line of treatment and a vast range of treatment.

Plants are utilized as remedial agents since time immemorial in both organized (Ayurveda, Unani) & Unorganized (folk, ethnic, inhabitant) form that have been revered for their medicinal value. Traditional system of medicines primarily Unani (Greco Arab) and Ayurveda uses plant as a whole or part of it for healing many ailments. Such as, A. eupatoria (Agrimonia/agrimony) is one of the most vital plants found in India which is used for its abiding properties of curing a number of diseases. The herb posses highly therapeutic value especially for treatment of lifestyle diseases such as Diabetes, Hypertension and Obesity, accompanied by low-grade inflammation.  Research on medicinal plants is one of the leading areas of research globally. Modern era researches and scientific reports also revalidate its usefulness as imperative medicinal herb. The integral objective of reviewing this manuscript is to bring to lime light the litrarery and scientific validation of Agrimonia eupatoria. Key words: Agrimonia, Unani Medicine, Traditional Medicine, Therapeutic Uses