Anti-inflammatory activity

The present study was designed to evaluate the in vitro antioxidant and anti-inflammatory activity of aqueous leaf extract of Teminalia catappa (ALTC).  Antioxidant activity of the ALTC was determined by following some well established methods for free radical scavenging such as superoxide, hydroxyl, hydrogen peroxide, nitric oxide and DPPH radical scavenging activities using ascorbic acid as standard. The anti-inflammatory activity was evaluated by using HRBC membrane stabilization assay and albumin denaturation assay using diclofenac as standard.  Treatment with ALTC showed dose dependent activity against superoxide, hydroxyl, hydrogen peroxide, nitric oxide and DPPH radicals. The ALTC showed significantly stabilization of membrane and denaturation of protein at a concentration range of 100-500µg/ml.  The antioxidant and anti-inflammatory activity of Teminalia catappa might be due to the anthocyanins in pericarp. Key words: Teminalia catappa, Antioxidant, Anti-inflammatory activity

Nonsteroidal anti-inflammatory (NSAIDs) drugs are generally used as a part of drug therapy in inflammation. However, these drugs have severe side-effects. Therefore, naturally originated compounds with very little side-effects are required to substitute chemical therapeutics and have better safety profile. Solanum sisymbriifolium (Family: Solanaceae) has many therapeutic uses mentioned in Ayurveda. Moreover, the plant has diverse pharmacological activity such as antihypertensive, diuretic, analgesic, contraceptive, antisyphilitic, hepatoprotective. Therefore, the present study was designed to investigate the preliminary phytochemical screening and anti-inflammatory activity of methanolic extract of roots of Solanum sisymbriifolium (MERS). Carrageenan-induced rat paw edema model was used for assessing the anti-inflammatory activity. The phytochemical analysis of MERS confirmed the presence of alkaloids, carbohydrates, flavanoids, terpenoids, tannins and saponins. Furthermore, MERS at doses of 50,100, 200 and 300 mg/kg showed anti-inflammatory activity in dose-dependent manner.