Drug Delivery

Acne is one of the most common disorders that dermatologists and other health care providers treat. Although it most often affects adolescents, it is not uncommon in adults and can also be seen in children.Acne is a tenacious incendiary human skin syndrome, mainly defined at particular areas of skin characterized by microcomedones, comedones, nodules, pustules, itchiness, as well as invasive scar mainly on different parts of the body. Acne is a chronic inflammatory disorder of pilosebaceous unit that occurs for chronic periodas a result of increased sebum production induced by androgen, altered keratinisation, inflammation, and bacterial colonisation of hair follicles on the face, neck, chest, and back by Propionibacterium acnes. Different nano-advancement techniques like vesicular, colloidal drug delivery system have been discussed. These systems can be useful in scheming a novel delivery with low dose treatment for the cure of acne vulgaris. The current review focused on the better nanotechnological system that can be used in future for better and effective treatment of acne.

Raloxifene loaded gellan gum nanoparticles were prepared using emulsion cross linking method.  A central composite design was applied to optimize the concentration of gellan gum, di-octyl sodium sulfosuccinate (AOT) and raloxifene to obtain an optimum formulation of gellan gum-raloxifene nanoparticles. The percentage of encapsulation, particle size and zetapotential were taken as response variables. A second order polynomial equation obtained from the regression analysis of the data was used to find the optimum level of the variables. The optimum concentrations were found to be gellan gum 1.31%, w/v, AOT 9.88%, w/v, raloxifene HCl (Drug) 1.08%, w/v. The optimized nanoparticle preparation showed 97% encapsulation, 256 nm particle size and zetapotential of -49 mV.