Stability studies.

Propranolol hydrochloride is a beta blocking agent which is used for the treatment of hypertension and it is highly lipophilic and completely absorbed after oral administration. The present study, Propranolol  hydrochloride  Mucoadhesive microspheres were formulated using  sodium alginate and the different concentration of polymers like Xanthan gum  and Guar gum by ionic gelation technique with  an  aim  to  controlled  release and improve bioavailability.  Six formulations were prepared by using different drug to polymer ratios, and evaluated for relevant parameters.  Depending upon the drug to polymer ratio, the percentage yield is found between 51.06±0.51% to 72.42±0.83 % in all formulations. The surface morphology of the microspheres was characterized by SEM. The prepared microspheres were discrete, spherical in shape and showed free flowing properties. The mean particle size of microspheres significantly increases with increasing polymer concentration and it was in the range between 23.10±0.12 µm to 33.66±0.41 µm. Among all the formulation, XG-III showed a high drug entrapment efficiency of 68.28±0.53 % and highest percentage swelling index of 67.75±0.06 %. The in-vitro drug release studies revealed that XG-III formulation is controlled and found to be 86.8±0.20 % and GG-III is found to be 89.8±0.11 % at the end of dissolution studies. The mechanism of drug release was evaluated using the linear regression coefficient. Stability studies of selected formulation showed good results. It could be also concluding that the all the formulations were shown satisfactory results and suitable for potential therapeutic uses.

Triphala-guggula vati a polyherbal Ayurvedic formulation is recommended in the management of pain in renal stone, it has dual action of aiding digestion and lowering body weight. It is effective in lowering cholesterol and reducing fat. It is also use in treatment of anal fistula, fissures and severe constipation. There has been an increase in demand for the Phyto-pharmaceutical products of Ayurveda so a pharmaceutical preparation in the form of Triphala-guggula vati was tried to standardize in terms of Fingerprinting and Stability studies, which is economical in terms of time and machinery usage. Literature survey indicates that no Fingerprinting and stability studies were carried out; hence present study was undertaken for the same. UV and HPTLC studies were carried out for finger printing of all important phytoconstituents of Triphala-guggula vati and its raw ingredients. HPTLC study were carried out on Aqueous and Alcoholic extracts using Camag HPTLC system equipped with Linomat V applicator, Camag TLC scanner 3 and CATS 4 software for interpretation of data. The laboratory batch and two Marketed preparations of Triphala-guggulu vati were subjected for development of rapid, reproducible, valid Fingerprinting method and stability testing method at standard recommended accelerated condition.